Cosmetic products stopped being mere vehicles for perfume or beautifying means: they interacted with a living tissue, i.e. the skin. There was at the time a growing awareness of the intolerance effects some
totally new products might entail. The first safety tests were thus conducted on animals (rats and rabbits). A few year later, the first in vitro tests to evaluate extracts on cultures of lactic bacteria and newt
eggs were proposed by Jean Cotte, hospital pharmacist, who later created the laboratory of dermopharmacy and cosmetology at the Faculty of Pharmacy in Lyons. As early as 1970, Monique Adolphe developed the first cell
cultures, as well as alternative methods to animal experimentation.
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Biochemistry knowledge of skin, by Jean Morelle. "La connaissance de la biochimie de la peau …", par Jean Morelle. Industrie de la parfumerie, 1953.
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| BIU Santé Pharmacie : cote P 10063. |
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Anatomy of skin sensitivity. "L’anatomie de la sensibilité cutanée", d’après G. Weddel, La Parfumerie moderne, 1948.
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| BIU Santé Pharmacie : cote P 15270. |
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