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V [Page de titre]
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VI
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VII [Dédicace]
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VIII
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IX Preface
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X
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XI Contents
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XII
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XIII
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XIV
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XV List of illustrations
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XVI
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1 Ergot and ergostism. Chapter 1. Ergot : historical / History and distribution of rye
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2
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3
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4 Ergot in England
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5 French names / Latin names / Italian names / Spanish / Portuguese / Rumanian / Danish / Norwegian / Swedish / Dutch / Russian
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6 German names
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7 Earliest references
Image : Fig. 1 : First mention of Ergot, by A. Lonicer, 1582
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8
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9
Image : Fig. 2 : Second mention of Ergot, by Thalius
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10
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Pl. interfol.
Image : Fig. 3 : First illustration of Ergot (From C. Bauhin's Theatrum Botanicum, ed. 1658)
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Verso
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11 Obsetetrical use of ergot in the eighteenth century
Image : Fig. 4 : First mention of Ergot in an English book
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12
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13
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14
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15
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16
Image : [Page de titre fac. sim. : A dissertation on the natural history and medicinal effects of the secal cornutum, or ergot / Oliver Prescott, 1813]
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17
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18
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19
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20 Chapter II. Ergotism. Relation between the two types
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21
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22
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23 Deficiency of vitamin A - a probable factor in convulsive ergotism
Image : Fig. 6 : Lesions of the Spinal Cord
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24
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25
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26 Amount of ergot required to produce the two types of ergotism
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27 Mixed epidemics
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28 Effect of ergot from hosts, other than rye, and of other impurities in corn
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29
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30 Description of gangrenous ergotism
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31 Description of convulsive ergotism
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32
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33
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34
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35
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36
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Pl. interfol.
Image : Fig. 7 : Gangrenous ergotism, Hungary, early 20th century (observed by Dr K. Chyzer) / Fig. 8 : Convulsive ergotism (Heusinger, 1856)
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Verso
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37
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38
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39 Bibliography of the history of ergotism
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40 Supposed references to ergot and ergotism by the ancients
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41
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42
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43 Ergotism in the Middle age
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44
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Pl. interfol.
Image : Fig. 9 : Fatal case of convulsive ergotism, 1909, in Bihar (S.E. Hungary, now Rumania) / Fig. 10 : Convulsive ergotism, hungary, early 20th century
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Verso
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45
Image : Fig. 11 : Ergotism in France
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46
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47
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48
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49
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50
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51
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52
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53
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54
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55
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56
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Pl. interfol.
Image : Fig. 12 [Saint Anthony blessing the victims of gangrenous ergotism] / Fig. 13 : Frescoes in the Chapel of St Anthony at Waltalingen, near Zürich (15th century), showing gangrenous and convulsive ergotism
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Verso
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57
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58
Image : Fig. 14 [Gravure sur bois : appeal to St Anthony by a peasant who has lost his right foot]
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59 Gangrenous ergotism in modern times
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60
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61
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62
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63
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64
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65 Convulsive ergotism in Germany and Bohemia
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66
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67
Image : Fig. 15 : Ergotism in Germany [Carte]
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68
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69
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70
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71
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72
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73
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74
Image : [Fig. 16 : Page de titre fac. sim. : Die Geschichte der Kriebel-Krankheit, besonders derjenigen welche in den Jahren 1770 und 1771 in den Zellischen Gegenden gewütet hat / Johann Taube, 1782]
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75
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76
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77
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78
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79 Convulsive ergotism in Sweden, Norway and Finland
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80 Ergotism in Russia
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81
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82
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83 Convulsive ergotism in other countries
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84
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85 Chapter III. Botanical. History
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86
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Pl. interfol.
Image : Fig. 17 : Ergot of Rye (natural size) / Fig. 18 : Ergot of Lolium (natural size) / Fig. 19 : Drop of Honey-dew on Lolium
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Verso
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87 Characters of tje sclerotium. Macroscopic characters / Micrography
Image : Fig. 20 : Fragment of a transverse section of the sclerotium, showing cortex (after Worthington Smith)
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88 Life cycle. Germination of the sclerotium
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Pl. interfol.
Image : Fig. 21 : Germinating sclerotium of Ergot of Rye / Fig. 22 : Later stage / Fig. 23 : Fully-developed capitula
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Verso
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89
Image : Fig. 24 : Section through capitulum showing perithecia (after Tulasne)
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90 The sexual process
Image : Fig. 25 : Section through perithecium / Fig. 26 : Asci and spores of Claviceps purpurea
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91 Dissemination and germination of ascospores
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92
Image : Fig. 27 : Germinating ascopores
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93 The sphacelia stage
Image : Fig. 28 : Claviceps purpurea
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94
Image : Fig. 29 : Portion of Claviceps purpurea / Fig. 30 : conidia in various stages of germination ; germinated conidia producing secondary conidia
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95
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96 Cultivation of the ergot fungus in pure culture as a saprophyte
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97 The spreading of ergot
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98 Ergot in relation to Agriculture. Conditions favouring the growth of ergot
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99 Measures for the control of ergot
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100 Cultivation of ergot in the field
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101
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102 Damage to agriculture
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103 Forecasting of "ergot" years
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104
Image : Fig. 31 : Ergotism in Cattle (after Marx)
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105 Species of claviceps
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106 A. European species
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107 B. American species
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108
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109
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110
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111
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112 Hosts of Claviceps and biological races
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113 Races of C. purpurea
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114
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115 Races of C. microcephala / Claviceps sesleriae
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116
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117 List of ergot hosts
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118
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119
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120
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121
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122
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123 Chapter IV. Chemical
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124
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125 A. Substances peculiar to ergot. Ergotinine and ergoxitine (hydro-ergotinine). Ergotinine
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126 Ergoxitine
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127
Image : Fig. 32 : ergotinine
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128
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129
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130
Image : Fig. 33 : ergotoxine / Fig. 34 : Ergotoxine phosphate
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131
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132 Colour reactions of the ergot alkaloids
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133 Constitution of ergotinine and ergotoxine
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134 Ergotamine and ergotaminine
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135
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136 Ergotamine
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137
Image : Fig. 35 : ergotamine
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138 Secal amino-sulphonic acid
Image : Fig. 36 : ergotamine phosphate / Fig. 37 : ergotaminine
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139 Coulouring matters. I. Sclererythrin
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140 II. Ergochrysin
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141 III. Ergoflavin. B. Substances not peculiar to ergot. Inorganic constituents
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142 Carbohydrates
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143 Glycerides and sterols
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144
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145 Acids
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146 Amino acids / Amines
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147 Other simple bases
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148
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149
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150
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151 Chapter V. Pharmacological and clinical
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152
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153 Pharmacological properties of ergotoxine (=hydroergotinine) and of ergotamine
Image : Fig. 38 : Vasomotor reversal. Pithed cat, 2 kilos. Carotid blood-pressure. The time marker shows ten-second intervals
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154
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155
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156
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157
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158
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159 Adreline / Ergotoxine / Adrenaline, after ergotoxine
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160
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161
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162
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163 General toxic effects
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164
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165
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166
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167 Pharmacological action of ergotinine and of ergotaminine
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168
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169 Tyramine, Isoamylamine
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170
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171 Histamine (Iminazolylethylamine
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172
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173
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174 Agmatine / Acetyl choline
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175 Clinical applications
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176
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177
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178
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179
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180
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181 Chapter VI. Pharmaceuticalc and forensic. Ergot in the pharmacopoeias
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182
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183
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184
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185
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186
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187 Special features
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188
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189 Chemical assay
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190
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191
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192
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193
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194 Biological assay
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195 1. Vasomotor reversal in the pithed cat 2. Abolition of the motor action of adrenaline on the isolated uterus if the rabbit
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196 3. Partial abolition of the motor action of adrenaline on the blood-vessels of the frog / 4. Abolition of the inhibition by adrenaline
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197 5. Reversal of the motor effect of histamine on the isolated guinea-pig's uterus / Cock's-comb method
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198
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199
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200
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201
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202 The blood-pressure method of assay / The isolated virgin guinea-pig's uterus
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203
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204 The alkaloidal content of ergot
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205 General properties of a good ergot
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206
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207 Some non-official ergots
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208
Image : Fig. 40 : Various ergots
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209 Proprietary preparations
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210
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211 Deterioration of ergot and of its preparations on keeping
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212 Deterioration of fluid extracts
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213
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214 Standards for biological assay
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215 Ergot in commerce
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216 Amount produced
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217 Centres of distribution / Fluctuation in price
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218
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219
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220 Ergot and public health
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221
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222
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223 Detection and estimation of ergot in flour and in bread
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224
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225
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226
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227
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228 Detection of ergot in bread
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229 Ergot in Forensio Medicine ; Detection in the Viscera
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230
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231 Bibliography and index of authors
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232
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233
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234
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235
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236
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237
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238
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239
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240
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241
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242
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243
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244
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245
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246
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247
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248
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249
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250
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251
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252
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253
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254
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255
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256
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257
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258
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259
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260
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261
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262
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263
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264
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265
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266
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267
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268
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269
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270
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271
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272
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273
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274
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275 Subject index
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276
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277
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278
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279
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